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Photoporation

A gentler cell transfection method

Photoporation is a gentle method to deliver payloads into cells based on the interaction between pulsed laser light and photothermal nanosensitizers.

View our
product video

Photoporation

A gentler cell transfection method

Photoporation is a gentle method to deliver payloads into cells based on the interaction between pulsed laser light and photothermal nanosensitizers.

View our
product video

LumiPoreTM - cell transfection platform

Photoporation is based on the interaction between pulsed laser light and photothermal nanosensitizers.

After incubation of cells with nanosensitizers, localized light-induced thermal and mechanical forces form transient pores in the cellular membrane. External payloads can enter the cellular cytosol through these pores with minimal impact on cell viability and functionality.

Our proprietary nanosensitizers can be used as a suspension for R&D applications or can be embedded in a nanofiber structure for clinical applications.

Gentle

Excellent
transfection yield

Flexible
applications

High throughput
and scalable

Minimal damage to the cell membrane means faster cell recovery and better preservation of functionality

Thanks to being gentle to cells, a high yield of transfected cells is achieved

Deliver a large variety of payloads (gene editing complexes, nucleic acids, contrast agents, proteins,…) to a broad range of cell types (immune cells, stem cells, neurons…)

No need for exchanging cell media – use in any transparent cell recipient (96-well plates, T-flasks, etc.)

Discover how it works

LumiPoreTM - cell transfection platform

Photoporation is based on the interaction between pulsed laser light and photothermal nanosensitizers.

After incubation of cells with nanosensitizers, localized light-induced thermal and mechanical forces form transient pores in the cellular membrane. External payloads can enter the cellular cytosol through these pores with minimal impact on cell viability and functionality.

Our proprietary nanosensitizers can be used as a suspension for R&D applications or can be embedded in a nanofiber structure for clinical applications.

Gentle

Minimal damage to the cell membrane means faster cell recovery and better preservation of functionality

Excellent
transfection yield

Thanks to being gentle to cells, a high yield of transfected cells is achieved

Flexible
applications

Deliver a large variety of payloads (gene editing complexes, nucleic acids, contrast agents, proteins,…) to a broad range of cell types (immune cells, stem cells, neurons…)

High throughput
and scalable

No need for exchanging cell media – use in any transparent cell recipient (96-well plates, T-flasks, etc.)

Discover how it works

Cell therapy manufacturing

Research and development

Increased
therapeutic potential

Reduced
vein-to-vein time

Faster
screening

Advanced
targeting

Minimal impact on cell viability,
homeostasis and functionality

Transfected cells recover
quickly and grow without delay

Transfect cells directly in typical cell culture recipients; transfected cells recover quickly

Spacially resolved transfections, down to single cell precision

Cell therapy manufacturing

Increased
therapeutic potential

Minimal impact on cell viability,
homeostasis and functionality

Reduced
vein-to-vein time

Transfected cells recover
quickly and grow without delay

Research and development

Faster
screening

Transfect cells directly in typical cell culture recipients; transfected cells recover quickly

Advanced
targeting

Spacially resolved transfections, down to single cell precision

Interested in using our
platform for your clinical
research or R&D applications?

Join our early access program

Our Investors

Learn more about Trince

Stay up to date on all
our latest research and news

News

Events

Read our latest news

Meet us at one of
these upcoming events

ASGCT

New Orleans, May 13-17, 2025

Trince Bio is also supported by a group of private investors.

Interested in using our platform for your clinical research or R&D applications?

Join our early access program

Our Investors

Trince Bio is also supported by a group of private investors.

Learn more about Trince

Events

Meet us at one of
these upcoming events

Stay up to date on all
our latest research and news