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Read Trince Bio's latest publications

White papers

Trince’s LumiPore™ technology enables efficient delivery of macromolecules in equine and human muscle derived mesenchymal stem cells

Photoporation: a promising strategy for the generation of engineered NK cell therapies

Gentle delivery of macromolecules in monocytes and macrophages by photoporation

LumiPore, a gentle non-viral transfection platform achieving high yields of mRNA delivery into various cell types

Posters

Transfection by photoporation enables inflammasome activation studies in targeted single cells

Photoporation: a promising strategy for CAR-NK cell therapy

Efficient and gentle non-viral engineering of IPSCs by photoporation

Publications

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Core technology (intracellular delivery)

Comparison of gold nanoparticle mediated photoporation: vapor nanobubbles outperform direct heating for delivering macromolecules in live cells. ACS Nano 8, 6288-6296 (2014). Xiong R., et al. (To the article)

Cytosolic delivery of nano-labels prevents their asymmetric inheritance and enables extended quantitative in vivo cell imaging. Nano Letters 16, 5975-5986 (2016). Xiong R., et al.  (To the article)

Laser-assisted photoporation: fundamentals, technological advances and applications. Advances in Physics: X 1, 596-620 (2016). Xiong R., et al. (To the article)

Comparing photoporation and nucleofection for delivery of small interfering RNA to cytotoxic T cells. Control. Release 267, 154-162 (2017). Wayteck L.,. J. (To the article)

Fast spatial-selective delivery into live cells. Control. Release 266, 198-204 (2017). Xiong R., et al.  (To the article)

 Selective Labeling of Individual Neurons in Dense Cultured Networks with Nanoparticle-enhanced Photoporation. Cell. Neurosci. 12, Article number 80 (2018). Xiong R., et al.  (To the article)

Repeated photoporation with graphene quantum dots enables homogeneous labelling of live cells with extrinsic markers for fluorescence microscopy. Light – Sci. Appl. 7, 47 (2018). Liu J., et al. (To the article)

 Targeted Perturbation of Nuclear Envelope Integrity with Vapor Nanobubble-Mediated Photoporation. ACS Nano 12, 7791–7802 (2018). Houthaeve G., et al. (To the article)

 Photothermally triggered endosomal escape and its influence on transfection efficiency of gold-functionalized JetPEI/pDNA nanoparticles. J. Mol. Sci. 19, Article Number 2400 (2018). Lotte Vemeulen, et al. (To the article)

Protein delivery by vapor nanobubble photoporation controls cell death modalities in tumor cells. J. Mol. Sci. 20, 4254 (2019). Van Hoecke L., et al. (To the article)

Gold nanoparticle-mediated photoporation for delivering macromolecules in human CD4+ T cells. Crystals 9, Art. Nr. 411 (2019).Laurens Raes, et al. (To the article)

Long-term live-cell microscopy with labeled nanobodies delivered by laser-induced photoporation. Nano Research 13, 485-495 (2020). Liu J., et al. (To the article)

Vapor Nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis. . J. Control. Release 319, 262-275 (2020). FraireC., et al. (To the article)

Surface Functionalization with Polyethylene Glycol and Polyethyleneimine Improves the Performance of Graphene-Based Materials for Safe and Efficient Intracellular Delivery by Laser-Induced Photoporation. J. Mol. Sci. 21, 1540 (2020). Liu J., Li C., et al. (To the article)

Intracellular labeling with extrinsic probes: delivery strategies and applications. Small, 16, Art. Nr. 2000146 (2020). Liu J., et al. (To the article)

Nanobody click chemistry for convenient site specific fluorescent labelling, single step immunocytochemistry and delivery into living cells by photoporation and live cell imaging. New Biotechnology, 59, 33-43 (2020). Hebbrecht T., et al. (To the article)

Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation. Nano-Micro Lett. 12, Article Number 185 (2020). Raes L., et al. (To the article)

 Physical transfection technologies for macrophages and dendritic cells in immunotherapy. Expert Opin. Drug Deliv. 18, 229-247 (2020). Harizaj A., et al. (To the article)

Nanoparticle-sensitized photoporation enables inflammasome activation studies in targeted single cells. Nanoscale 13, 6592-6604 (2021). Harizaj A., et al. (To the article)

Stimuli-responsive Nanobubbles for Biomedical Applications. Soc. Rev. 50, 5746-5776 (2021). Xiong R., et al. (To the article)

Vapor Nanobubble-Mediated Photoporation Constitutes a Versatile Intracellular Delivery Technology. Opin. Colloid. In. 54, Art. 101453 (2021). Ramon J., et al. (To the article)

Cytosolic delivery of gadolinium via photoporation enables improved in vivo magnetic resonance imaging of cancer cells. Sci. 9, 4005-5018 (2021). Harizaj A., et al.  (To the article)

Photoporation with biodegradable polydopamine nanosensitizers enables safe and efficient delivery of mRNA in human T cells. Adv. Mater. 31, Art. 2102472 (2021). Harizaj A., et al. (To the article)

 Non-viral transfection technologies for next-generation therapeutic T cell engineering. Biotechnol. Adv. 49, Art. 107760 (2021). Raes L., et al. (To the article)

Photothermal nanofibers enable safe engineering of therapeutic cells. Nanotechnol. Accepted (2021). Xiong R., et al. (To the article)

 Cas9 RNP Transfection by Vapor Nanobubble Photoporation for Ex Vivo Cell Engineering. Raes L., et al.  (To the article)

Other applications of ‘photoporation’

Vapour Nanobubbles Improve Drug Diffusion and Efficiency in Bacterial Biofilms. Nature Communications 9, Article Number 4518 (2018). Teirlinck E., et al. (To the article)

Exploring Light-Sensitive Nanocarriers for Simultaneous Triggered Antibiotic Release and Disruption of Biofilms upon Generation of Laser-Induced Vapor Nanobubbles. Pharmaceutics 11, 201 (2019). Teirlinck E., et al. (To the article) 

Laser-induced vapor nanobubbles improve diffusion in biofilms of antimicrobial agents for wound care. Biofilm 1, 100004 (2019). Teirlinck E., et al. (To the article)

Photoablation of human vitreous opacities by light-induced vapor nanobubbles. ACS Nano 13, 8401-8416 (2019). Sauvage F., et al. (To the article)

Does the mode of dispersion determine the properties of dispersed Pseudomonas aeruginosa biofilm cells? J. Antimicrob. Agents, 56, Article Number 106194 (2020). Wille J.,et al. (To the article)

Bubble forming films for spatial selective cell killing. Mater. 33, Art. 2008379 (2021). Hua D.*, et al. (To the article)

Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters. Nanoscale Horiz. 6, 449-461 (2021). Barras A., et al. (To the article)

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